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Rituximab treatment of myasthenia gravis: J Biol Chem, 18 Rituximab is a promising treatment for refractory MuSK-MG; in uncontrolled studies, nearly all treated patients achieved significant improvement with substantial decrease of medication. The relationship between high-sensitivity CRP and polyclonal free light chains as markers of inflammation in chronic disease.
Serological Immunoglobulin-Free Light Chain Profile in Myasthenia Gravis Patients
Curr Opin Drug Disc, 12 5 Current Opinion in Bartoccioi. The statistical analysis revealed significant differences between patients and HBD: Substrate binding tunes conformational flexibility and kinetic stability of an amino acid antiporter. Also, changes of T and B cell subsets were evaluated as possible biomarkers of 212 activity and eventually as therapeutic targets [ 21 ]. Bartoccioni pdf J Biol Chem, 43 Facilitator system l amino acid transporters and the orphan EEG1.
Paola Chiara Bartoccioni
High-dose prednisone plus plasma exchange is the recommended approach for treating 20122 progressive bulbar weakness. The renal handling of low molecular weight proteins. Long-lasting treatment effect of rituximab in MuSK myasthenia. This article has been corrected. Patients with low anti-AChR antibody levels.
Or filter your current search. Its treatment can be unrewarding, owing to poor response to acetylcholinesterase inhibitors in most patients, disease relapses in spite of high-dose immunosuppression, and development of permanent bulbar weakness. Laboratory Testing Sera were obtained by standard centrifugation, divided into aliquots, and stored frozen until analysis. Our goal, however, was to conduct a pilot study on serum levels of FLCs and IgG subclasses in an organ-specific autoimmune disease like MG.
Thanks to their short half-life, and in subjects with normal kidney function, their serum levels can be considered as a direct marker of B cell activity, which is otherwise difficult to measure in routine clinical practice.
It is confirmed by the combination of typical symptoms and signs, electromyographic and pharmacological tests, as well as by the detection of specific auto-abs. Being a by-product of intact immunoglobulin synthesis, they may represent a marker of overall B cell activity, particularly in those diseases where there is an increased formation of immune complexes like systemic autoimmune disorders.
Normal range for subclasses: Serum free light chains as biomarkers for systemic lupus erythematosus disease activity.
Auto-abs bind to well-defined antigens in the postsynaptic membrane at the neuromuscular junction and impair nerve-muscle transmission, which in turn induces muscle weakness and excessive fatigability. FLCs have never been investigated in MG but could be useful to predict possible variations of B cell activity, which can influence the clinical picture both in the short and in the long range.
J Physiol-London, Pt 24 Supplementary Materials Supplementary 1 Table S1: There is a great need for biomarkers in MG to identify patients at risk for disease flares, monitor response to treatment, and be a guide to a better management of immunosuppression.
As MG course may be remarkably variable, we evaluated the possible use of FLCs as biomarkers of disease activity.
Immunoglobulin- Ig- free light chains FLCs are produced in excess of heavy chains during the synthesis of intact Ig by plasma cells [ 1 ] and contribute to inflammation in experimental disease models [ 2 ].
A 5-year follow-up of rituximab treatment in patients with neuromyelitis optica spectrum disorder. How does Europe PMC derive its citations network? Serological levels of free immunoglobulin light chains FLCsproduced in excess of heavy chains during synthesis of immunoglobulins by plasma cells, can be considered a direct marker of B cell activity in different systemic inflammatory-autoimmune conditions and may represent a useful predictor of rituximab RTX therapeutic efficacy, as reported for rheumatoid arthritis and systemic lupus erythematosus.
PLoS One, 10 9e It doesnt just compare the size and date of files, either; it does Bartoccioni Pdf Download bytebybyte check to ensure no changes go undetected. Click here for additional data file. Hum Mol Genet, 17 12 We assessed FLC levels in 34 sera from 17 AChR-MG and from 13 MuSK-MG patients, in comparison with 20 sera from patients with systemic autoimmune rheumatic diseases and 18 from healthy blood donors, along with titers of specific auto-abs and IgG subclass distribution.
P Natl Acad Sci Usa, 8 Find all citations in this journal default.
The Journal of Rheumatology. Autoantibody-producing plasmablasts after B cell depletion identified in muscle-specific kinase myasthenia gravis. Embo J, 32 17 In this scenario, FLC determination seems to be a sensitive index of B cell activation even in organ-specific disorders where the autoimmune response is limited at a well-defined, single autoantigen. Sanders, MD bartoccinoi gravis MG.